The Queen star will play Britain's monarch Queen Elizabeth II again in The Audience, a new play by Peter Morgan, the screenwriter behind Mirren's royal movie.
However, despite her lengthy career, the actress admits she still battles crippling nerves.
She tells Britain's Woman & Home magazine, ""I still suffer terribly from stage fright. I get sick with fear. Not every night, but at the beginning and on occasion - not necessarily when I'm expecting it. You just have to take it on the chin and work through it, trying to use the adrenaline to perform.""
The Audience is set to debut in London next month (Feb13).