Qualley makes her debut as MacDowell's eldest daughter Maddie in the forthcoming film, about a man who struggles with bipolar disorder and the effect it has on his family.
But MacDowell reveals their first shoot together was far from easy, admitting she felt uncomfortable when Qualley acted out her intense scenes.
She tells the Daily Mail's Weekend magazine, ""In (Mighty Fine), I'm married to a man who's bipolar and takes it out on our daughter, and I don't protect her. The role was very demanding, very abusive. What my daughter went through makes me cringe.""